Pacinian collagenoma

Br J Dermatol. 1999 Jul;141(1):119-22. doi: 10.1046/j.1365-2133.1999.02931.x.


An unusual histological variant of collagenoma is described. A 36-year-old woman presented with a lump in the left hypothenar eminence. Histological examination revealed a well-delineated lesion composed of paucicellular collagen fibres arranged in concentric lamellations giving rise to an onion skin appearance. The overlying epidermis was thin and the lateral borders were demarcated by an epidermal collarette. Inflammation and xanthoma cells were absent and occasional capillaries were present. The lesion was positive for collagen stains, reticulin and CD34. This lesion represents an uncommon histological form of collagenoma or fibroma. It can be distinguished from histological look-alikes on the basis of the characteristic morphology and immunophenotype.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD34 / analysis
  • Collagen / analysis*
  • Diagnosis, Differential
  • Female
  • Fibroma / immunology
  • Fibroma / metabolism
  • Fibroma / pathology*
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Pacinian Corpuscles
  • Skin Neoplasms / immunology
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*


  • Antigens, CD34
  • Collagen