[Nasopharyngeal carriage of resistance pneumococci in day-care centers in the Alps-Maritimes region]

Pathol Biol (Paris). 1999 May;47(5):478-82.
[Article in French]

Abstract

To provide ongoing information on regional trends of antibiotic resistance prevalence to pneumococci, a cross selectional survey was conducted on a large representative sample of children attending day-care centers. Children were analyzed in spring (n = 378) and autumn (n = 379) for nasopharyngeal carriage. Streptococcus pneumoniae was detected in 149 children (39.4%) in Spring and 204 (59.8%) in Autumn. Half of these isolated strains showed penicillin insensitivity or resistance. A high proportion of children (43.6% in spring and 47.5% in autumn) had been treated with antibiotics during the 3 months prior to sample collection; 21.6% of isolated strains were serotype 6B, 20.1% type 23F, 18.9% type 19A and 19F, 11.5% type 14. Reduced susceptibility was frequently noted in serotype 23F, 14 and 19F, representing 93%, 94% and 46% of identified serotypes, respectively. Acquisition of a strain of PRP was correlated with prescription of antibiotics during the previous three months (p < 0.05). This type of survey on children in day-care centers can contribute to the understanding of regional variations in antibiotic resistance and provide information for epidemiological surveillance.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Child Day Care Centers*
  • Child, Preschool
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology*
  • Community-Acquired Infections / transmission
  • Drug Resistance, Microbial*
  • Female
  • France / epidemiology
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Nasal Mucosa / microbiology*
  • Penicillin Resistance
  • Pharynx / microbiology*
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / transmission*
  • Risk Factors
  • Serotyping
  • Smoking
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / isolation & purification*