Azaanthraquinone: an antimicrobial alkaloid from Mitracarpus scaber

Planta Med. 1999 Jun;65(5):447-8. doi: 10.1055/s-2006-960807.

Abstract

An ethanolic extract of the aerial parts of Mitracarpus scaber demonstrated good antimicrobial activity. Bioassay directed fractionation of this extract led to the isolation of benz[g]isoquinoline-5,10-dione (1) as an active component. Compound 1 showed significant in vitro inhibitory activity against the AIDS-related pathogens.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Candida albicans / drug effects
  • Cryptococcus neoformans / drug effects
  • Isoquinolines / chemistry
  • Isoquinolines / isolation & purification
  • Isoquinolines / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium avium Complex / drug effects
  • Plant Extracts*
  • Plant Leaves
  • Plants, Medicinal*
  • Staphylococcus aureus / drug effects

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Isoquinolines
  • Plant Extracts
  • benzo(g)isoquinoline-5,10-dione