Abstract
An ethanolic extract of the aerial parts of Mitracarpus scaber demonstrated good antimicrobial activity. Bioassay directed fractionation of this extract led to the isolation of benz[g]isoquinoline-5,10-dione (1) as an active component. Compound 1 showed significant in vitro inhibitory activity against the AIDS-related pathogens.
Publication types
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Letter
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology*
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Microbial Sensitivity Tests
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Mycobacterium avium Complex / drug effects
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Plant Extracts*
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Plant Leaves
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Plants, Medicinal*
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Staphylococcus aureus / drug effects
Substances
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Alkaloids
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Isoquinolines
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Plant Extracts
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benzo(g)isoquinoline-5,10-dione