Immunogenicity and reactogenicity in UK infants of a novel meningococcal vesicle vaccine containing multiple class 1 (PorA) outer membrane proteins

Vaccine. 1999 Jun 4;17(20-21):2612-9. doi: 10.1016/s0264-410x(99)00044-4.


The development of effective vaccines against serogroup B meningococci is of great public health importance. We assessed a novel genetically engineered vaccine containing six meningococcal class 1 (PorA) outer membrane proteins representing 80% of prevalent strains in the UK. 103 infants were given the meningococcal vaccine at ages 2, 3 and 4 months with routine infant immunisations, with a fourth dose at 12-18 months. The vaccine was well tolerated. Three doses evoked good immune responses to two of six meningococcal strains expressing PorA proteins contained in the vaccine. Following a fourth dose, larger bactericidal responses to all six strains were observed, suggesting that the initial course had primed memory lymphocytes and revaccination stimulated a booster response. This hexavalent PorA meningococcal vaccine was safe and evoked encouraging immune responses in infants. Vaccines of this type warrant further development and evaluation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood
  • Bacterial Vaccines / immunology*
  • Female
  • Humans
  • Infant
  • Male
  • Neisseria meningitidis / immunology*
  • Porins / immunology*
  • Vaccines, Synthetic / immunology*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Porins
  • Vaccines, Synthetic
  • porin protein, Neisseria