Oral bedtime cornstarch supplementation reduces the risk for nocturnal hypoglycaemia in young children with type 1 diabetes

Acta Paediatr. 1999 Jun;88(6):595-7. doi: 10.1080/08035259950169215.


The effect of oral cornstarch supplementation was evaluated in 14 pre-school children with type 1 diabetes in a randomized, double-blind, placebo-controlled trial. The children received cornstarch (0.3 g/kg) or placebo at bedtime on five occasions each, and their blood glucose concentrations were measured at bedtime, at 02.00 h and in the morning. The mean nocturnal blood glucose concentration (at 02.00 h) was 2.2 mmol/L higher and the number of blood glucose concentrations below 5 mmol/L were reduced by 64% when cornstarch had been ingested at bedtime. We conclude that cornstarch may be used in pre-school children with type 1 diabetes to reduce the risk for nocturnal hypoglycaemia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Blood Glucose / analysis
  • Child
  • Child, Preschool
  • Circadian Rhythm*
  • Diabetes Mellitus, Type 1 / complications*
  • Dietary Supplements*
  • Double-Blind Method
  • Eating
  • Female
  • Humans
  • Hypoglycemia / blood
  • Hypoglycemia / etiology*
  • Hypoglycemia / prevention & control*
  • Male
  • Severity of Illness Index
  • Starch / therapeutic use*
  • Time Factors


  • Blood Glucose
  • Starch