Abstract
The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review summarizes our current knowledge regarding these compounds. Novel aspects of the biochemistry and bioactivity of IsoPs are detailed and methods by which these compounds are analyzed are discussed. A considerable portion of this review deals with the utility of measuring IsoPs as markers of oxidant injury in human diseases particularly in association with risk factors that predispose to atherosclerosis, a condition in which excessive oxidative stress has been causally implicated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Arachidonic Acid / chemistry
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Arachidonic Acid / metabolism*
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Arteriosclerosis / metabolism
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Chemistry Techniques, Analytical / methods
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Diabetes Mellitus / metabolism
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Free Radicals
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Homocysteine / blood
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Humans
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Hypercholesterolemia / metabolism
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Isomerism
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Lipid Peroxidation
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Oxidative Stress*
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Prostaglandins / chemistry*
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Prostaglandins / classification
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Prostanoic Acids / chemistry*
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Prostanoic Acids / metabolism
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Smoking
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Thromboxanes / chemistry
Substances
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Free Radicals
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Prostaglandins
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Prostanoic Acids
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Thromboxanes
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Homocysteine
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Arachidonic Acid