Confocal microscopy in posterior polymorphous corneal dystrophy

Ophthalmologica. 1999;213(4):211-3. doi: 10.1159/000027423.


Purpose: To report the distinguishing characteristics of posterior polymorphous corneal dystrophy (PPMD) using confocal microscopy.

Material and methods: Two consecutive patients with PPMD were prospectively examined using a white-light tandem scanning confocal microscope with a 24x/0.60 contact objective.

Results: At the level of Descement's membrane, roundish hyporeflective images were found in 1 patient. In the other patient, hyporeflective bands were detected. In both patients, patchy hyperreflective areas were identified.

Conclusion: Confocal microscopy may allow diagnosis of PPMD by demonstrating the alterations in Descement's membrane. This technique is especially valuable in cases of endothelial decompensation, where slit-lamp and specular microscopy may fail to demonstrate changes in Descement's membrane.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Corneal Dystrophies, Hereditary / pathology*
  • Descemet Membrane / pathology
  • Female
  • Humans
  • Microscopy, Confocal*
  • Middle Aged
  • Prospective Studies
  • Video Recording