Codon 72 polymorphism of p53 and its association with cervical cancer

Lancet. 1999 Jul 17;354(9174):218-9. doi: 10.1016/S0140-6736(99)01914-5.

Abstract

Swedish and Italian women with HPV 16-positive cervical disease were checked for codon 72 polymorphisms of p53. In both groups, arginine homozygotes were enriched in cancer compared with controls and precursor lesions.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / virology
  • Case-Control Studies
  • Cervical Intraepithelial Neoplasia / genetics*
  • Cervical Intraepithelial Neoplasia / virology
  • Codon
  • Female
  • Genes, p53 / genetics*
  • Genotype
  • Humans
  • Italy
  • Papillomaviridae / isolation & purification*
  • Polymorphism, Single-Stranded Conformational*
  • Sweden
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / virology

Substances

  • Codon