Genetic recombination: Helicases and topoisomerases link up

Curr Biol. 1999 Jul 15;9(14):R518-20. doi: 10.1016/s0960-9822(99)80325-x.

Abstract

RecQ helicases and topoisomerase III are both required for genome stability, particularly to prevent 'promiscuous' genetic recombination. A recent study demonstrates that, together, these enzymes can catalyse the interlinking of plasmid DNA, and suggests a novel mechanism for the control of recombination.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • DNA Helicases / genetics*
  • DNA Topoisomerases, Type I / genetics*
  • DNA-Binding Proteins / metabolism
  • Escherichia coli / genetics
  • Genes, Fungal / genetics
  • Humans
  • Models, Genetic
  • Nucleic Acid Conformation
  • Phenotype
  • Plasmids / genetics
  • RecQ Helicases
  • Recombination, Genetic*

Substances

  • DNA-Binding Proteins
  • Adenosine Triphosphatases
  • RECQL protein, human
  • RecQ protein, E coli
  • DNA Helicases
  • RecQ Helicases
  • DNA Topoisomerases, Type I