Kinase phosphorylation: Keeping it all in the family

Curr Biol. 1999 Jul 15;9(14):R521-4. doi: 10.1016/s0960-9822(99)80326-1.

Abstract

The identification of PDK1 as a kinase that phosphorylates the AGC family of kinases led to a hunt for 'PDK2', a hypothetical regulated kinase(s) that would be required for full activation of the AGC kinases. Recent findings suggest that the elusive PDK2 may actually be a familiar kinase with an atypical associate.

Publication types

  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases
  • Amino Acid Sequence
  • Cyclic Nucleotide-Regulated Protein Kinases / metabolism*
  • Cyclic Nucleotide-Regulated Protein Kinases / physiology*
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / physiology
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Sequence Homology, Amino Acid

Substances

  • Proto-Oncogene Proteins
  • Cyclic Nucleotide-Regulated Protein Kinases
  • 3-Phosphoinositide-Dependent Protein Kinases
  • PDPK1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt