Solid-phase total synthesis of polymyxin B1

J Pept Res. 1999 May;53(5):501-6. doi: 10.1034/j.1399-3011.1999.00045.x.


The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synthesized in high yields using solid-phase synthesis. According to MS and HPLC, the synthetic peptide was identical to the naturally occurring antibiotic.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Mass Spectrometry
  • Models, Molecular
  • Polymyxin B / analogs & derivatives*
  • Polymyxin B / chemical synthesis
  • Polymyxins* / analogs & derivatives*


  • Polymyxins
  • polymyxin B(1)
  • Polymyxin B