Transmitochondrial mice carrying resistance to chloramphenicol on mitochondrial DNA: developing the first mouse model of mitochondrial DNA disease

Nat Med. 1999 Aug;5(8):957-60. doi: 10.1038/11403.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Cell Fusion
  • Chimera / genetics*
  • Chloramphenicol O-Acetyltransferase / pharmacology*
  • DNA, Mitochondrial / genetics*
  • Disease Models, Animal*
  • Drug Resistance
  • Female
  • Hybrid Cells*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microinjections
  • Oocytes
  • Phenotype
  • Point Mutation
  • RNA, Ribosomal, 16S / genetics
  • Stem Cells

Substances

  • DNA, Mitochondrial
  • RNA, Ribosomal, 16S
  • Chloramphenicol O-Acetyltransferase