Sarcoidosis in a patient with AIDS: a manifestation of immune restoration syndrome

J Am Acad Dermatol. 1999 Aug;41(2 Pt 2):285-6. doi: 10.1016/s0190-9622(99)70364-6.


Sarcoidosis has been rarely reported in the presence of HIV infection. Helper T-lymphocyte depletion may attenuate granuloma formation. We present a patient who developed active sarcoidosis after being started on highly active antiretroviral therapy (HAART), which increased his CD4 count and decreased his viral load. There have been reports of exaggerated responses to mycobacteria and viruses with the restoration of T-cell function after HAART in HIV-infected patients. We propose that active sarcoidosis seen in this patient is also a manifestation of this newly observed "immune restoration disease."

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • Acute Disease
  • Anti-HIV Agents / administration & dosage
  • CD4 Lymphocyte Count
  • Humans
  • Male
  • Middle Aged
  • Sarcoidosis / complications*
  • Sarcoidosis / pathology
  • Skin / pathology
  • Viral Load


  • Anti-HIV Agents