Angiogenesis is prognostically important in vertical growth phase melanomas

Int J Oncol. 1999 Sep;15(3):595-9. doi: 10.3892/ijo.15.3.595.


The association between microvessel density (MVD) and patient survival has recently been established for various types of human cancers. Immunohistochemical staining (factor-VIII related antigen) was performed on a series of 102 vertical growth phase melanomas and vessels were counted in <hot spot> areas. Increased MVD was associated with large histologic tumor diameter (p=0.006) and tumor ulceration (p=0.04). Further, high vascular density was significantly related to decreased patient survival (p=0.04), with borderline significance (p=0.10) in the final multivariate model. The results of this study suggest that microvessel density is of prognostic importance in aggressive vertical growth phase melanomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division / physiology
  • Disease-Free Survival
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanoma / blood supply
  • Melanoma / mortality
  • Melanoma / pathology*
  • Middle Aged
  • Multivariate Analysis
  • Neovascularization, Pathologic*
  • Prognosis
  • Retrospective Studies