Treatment of Alzheimer's disease: an evaluation of the cholinergic approach

Acta Neurol Belg. 1999 Jun;99(2):96-106.

Abstract

The cholinergic hypothesis claims that a decrease of acetylcholine (ACh) in the brain of patients with Alzheimer's Disease (AD) plays an important role in the deterioration of cognitive functioning. This hypothesis has led to extensive research in possible therapeutic approaches towards improving cholinergic transmission in AD patients. The different approaches have focused on the following six strategies: ACh precursors, ACh release, M1, M3, or M4 receptor agonists, M2 receptor antagonists, nicotinic agonists, and acetylcholinesterase inhibitors (AChEI). The aim of this review is to assess the effectiveness of the cholinergic approach for the treatment of AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholine / biosynthesis
  • Acetylcholine / physiology*
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / physiopathology
  • Animals
  • Carbamates / therapeutic use
  • Chemical and Drug Induced Liver Injury / etiology
  • Cholinergic Agents / adverse effects
  • Cholinergic Agents / therapeutic use*
  • Cholinergic Fibers / physiology
  • Cholinesterase Inhibitors / adverse effects
  • Cholinesterase Inhibitors / therapeutic use*
  • Clinical Trials as Topic
  • Donepezil
  • Double-Blind Method
  • Drug Evaluation, Preclinical
  • Humans
  • Indans / therapeutic use
  • Nootropic Agents / adverse effects
  • Nootropic Agents / therapeutic use*
  • Phenylcarbamates*
  • Piperidines / therapeutic use
  • Randomized Controlled Trials as Topic
  • Receptors, Cholinergic / drug effects*
  • Receptors, Muscarinic / classification
  • Receptors, Muscarinic / drug effects
  • Receptors, Nicotinic / drug effects
  • Rivastigmine
  • Tacrine / adverse effects
  • Tacrine / therapeutic use

Substances

  • Carbamates
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Indans
  • Nootropic Agents
  • Phenylcarbamates
  • Piperidines
  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • Receptors, Nicotinic
  • Tacrine
  • Donepezil
  • Acetylcholine
  • Rivastigmine