Characterization of processed tooth hydroxyapatite for potential biomedical implant applications

Artif Cells Blood Substit Immobil Biotechnol. 1999 Jul;27(4):367-79. doi: 10.3109/10731199909117706.


In this study hydroxyapatite (HA) (100-150 microns) derived from freshly-extracted human teeth in laboratory conditions was investigated. Scanning electron microscope (SEM), energy dispersive x-ray spectroscopy (EDXS), wet chemical, ion chromatographic peak method (ICP), atomic absorption, x-ray diffraction and infra-red (IR) were performed separately for HA obtained from dentine and enamel. This naturally derived HA did not differ from synthetic ones. Its production was simple when compared with other methods. Processed tooth HA could safely be used in animal subjects prior to human studies as a graft material after biocompatibility studies fully conducted.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / isolation & purification*
  • Bone Substitutes / chemical synthesis
  • Bone Substitutes / chemistry
  • Bone Substitutes / isolation & purification
  • Durapatite / chemical synthesis
  • Durapatite / chemistry
  • Durapatite / isolation & purification*
  • Humans
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Prostheses and Implants*
  • Spectrophotometry, Atomic
  • Spectrophotometry, Infrared
  • Spectrum Analysis
  • Tooth / chemistry*
  • X-Ray Diffraction
  • X-Rays


  • Biocompatible Materials
  • Bone Substitutes
  • Durapatite