Sexual development in a two-year-old boy induced by topical exposure to testosterone

Pediatrics. 1999 Aug;104(2):e23. doi: 10.1542/peds.104.2.e23.


Virilization, including penile enlargement and growth of pubic hair and facial acne, developed in a 2-year-old boy over a period of months. This sexual development was induced by incidental and unintentional dermal exposure to a testosterone cream that was applied to his father's arm and back as a part of body building regimen. Except for penile size, the other signs of virilization diminished several months after the exposure was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Child, Preschool
  • Humans
  • Male
  • Puberty, Precocious / chemically induced*
  • Testosterone / adverse effects*


  • Testosterone