Tumor staging of pancreatic adenocarcinoma using early- and late-phase helical CT

AJR Am J Roentgenol. 1999 Aug;173(2):375-80. doi: 10.2214/ajr.173.2.10430140.


Objective: We compared early-phase CT with late-phase CT in the evaluation of pancreatic adenocarcinoma.

Materials and methods: Both early- and late-phase CT images of 25 pancreatic adenocarcinomas were compared with surgical-pathologic findings. We evaluated tumor detectability, tumor size, and local tumor invasion.

Results: Tumor detectability was 96% on early-phase CT imaging and 64% on late-phase CT imaging (p < .01). Sensitivity for anterior serosal invasion, retroperitoneal invasion, and arterial invasion on early-phase CT exceeded sensitivity on late-phase CT (p < .05). However, specificity for all factors on early-phase CT was less than or equal to specificity on late-phase CT. The grade of local tumor invasion on early-phase CT achieved better agreement with the surgical-pathologic results than did late-phase CT, especially for tumor size and retroperitoneal invasion.

Conclusion: Early-phase CT was better than late-phase CT in revealing tumors, tumor size, and retroperitoneal invasion.

MeSH terms

  • Adenocarcinoma / diagnostic imaging*
  • Adenocarcinoma / pathology*
  • Aged
  • Carcinoma, Adenosquamous / diagnostic imaging*
  • Carcinoma, Adenosquamous / pathology*
  • Cystadenocarcinoma, Mucinous / diagnostic imaging*
  • Cystadenocarcinoma, Mucinous / pathology*
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Pancreas / diagnostic imaging
  • Pancreas / pathology
  • Pancreatic Neoplasms / diagnostic imaging*
  • Pancreatic Neoplasms / pathology*
  • Sensitivity and Specificity
  • Time Factors
  • Tomography, X-Ray Computed / methods*
  • Tomography, X-Ray Computed / statistics & numerical data