The urinary excretion of deoxypyridinium cross-links is higher in diabetic than in nondiabetic adolescents

Calcif Tissue Int. 1999 Aug;65(2):121-4. doi: 10.1007/s002239900668.


We have measured the urinary excretion of deoxypyridinium (D-Pyr) crosslinks, a sensitive and specific marker of bone resorption, in morning urine in 102 healthy, nonhospitalized, Caucasian subjects (8-18 years) and in 18 diabetic subjects (12-17 years). The free D-Pyr crosslinks were measured using the Pyrilinks D-Assay. In the diabetic subjects, plasma glucose was regulated throughout the night by a constant infusion of insulin and a variable infusion of 24% glucose. In the nondiabetic subjects, the excretion of D-Pyr increased until 12-14 years of age, and thereafter decreased, and the excretion of D-Pyr/hour was correlated with the height Z-score. The excretion of D-Pyr/hour and the D-Pyr/creatinine ratio was higher in the diabetic adolescents than in the nondiabetic adolescents. In subjects over the age of 12, the D-pyr/creatinine ratio was higher in males than in females. In conclusion, in healthy children and adolescents, the excretion of D-Pyr peaks at 12-14 years of age. The D-Pyr excretion is higher in diabetic than in nondiabetic adolescents, suggesting increased bone resorption in diabetic adolescents.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Amino Acids / urine*
  • Blood Glucose / metabolism
  • Bone Resorption / urine
  • Child
  • Creatinine / urine
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / urine*
  • Female
  • Humans
  • Insulin / therapeutic use
  • Male
  • Reference Values


  • Amino Acids
  • Blood Glucose
  • Insulin
  • deoxypyridinoline
  • Creatinine