Lipoprotein(a): intrigues and insights

Curr Opin Lipidol. 1999 Jun;10(3):225-36. doi: 10.1097/00041433-199906000-00005.


Lipoprotein(a) is an atherogenic, cholesterol ester-rich lipoprotein of unknown physiological function. The unusual species distribution of lipoprotein(a) and the extreme polymorphic nature of its distinguishing apolipoprotein component, apolipoprotein(a), have provided unique challenges for the investigation of its biochemistry, genetics, metabolism and atherogenicity. Some fundamental questions regarding this enigmatic lipoprotein have escaped elucidation, as will be highlighted in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Apolipoproteins / genetics
  • Apoprotein(a)
  • Arteriosclerosis / blood
  • Biological Evolution
  • Clinical Trials as Topic
  • Humans
  • Lipoprotein(a) / blood*
  • Lipoprotein(a) / physiology


  • Apolipoproteins
  • Lipoprotein(a)
  • Apoprotein(a)