3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues

I Fedorov; E Kazmina; M Jasko; J Balzarini; E De Clercq; J P Sommadossi; J L Imbach; G Gosselin

doi:10.1080/15257779908041522

3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):633-4. doi: 10.1080/15257779908041522.

Authors

I Fedorov¹, E Kazmina, M Jasko, J Balzarini, E De Clercq, J P Sommadossi, J L Imbach, G Gosselin

Affiliation

¹ Moscow Medical Sechenov Academy, Russia.

PMID: 10432655
DOI: 10.1080/15257779908041522

Abstract

A series of 3'-(N-hydroxyimino)-2',3'-dideoxynucleosides bearing different nucleic bases has been prepared. In vitro antiviral activity studies showed that among these compounds the thymine derivative possesses significant activity against HIV, HSV, EBV and HBV. Conveniently 5'-protected 3'-(N-hydroxyimino)-2',3'-dideoxythymidine was further used as a synthon for the preparation of other nucleoside analogues.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology*
Dideoxynucleosides / chemical synthesis*
Dideoxynucleosides / pharmacology*
HIV / drug effects
Herpesviridae / drug effects
Microbial Sensitivity Tests

Substances

Antiviral Agents
Dideoxynucleosides