Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity

P Franchetti; G Abu Sheikha; L Cappellacci; M Grifantini; E Balestra; C F Perno; G Brandi; L Rossi; M Magnani

doi:10.1080/15257779908041624

Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):989-90. doi: 10.1080/15257779908041624.

Authors

P Franchetti¹, G Abu Sheikha, L Cappellacci, M Grifantini, E Balestra, C F Perno, G Brandi, L Rossi, M Magnani

Affiliation

¹ Dipartimento di Scienze Chimiche, Università di Camerino, Italy.

PMID: 10432727
DOI: 10.1080/15257779908041624

Abstract

A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / pharmacology
Antiviral Agents / chemical synthesis
Antiviral Agents / pharmacology
Cells, Cultured
HIV-1 / drug effects*
Herpesvirus 1, Human / drug effects*
Humans
Macrophages / drug effects
Macrophages / virology
Microbial Sensitivity Tests
Nucleosides / chemical synthesis*
Nucleosides / pharmacology

Substances

ACVpPMPA
Anti-HIV Agents
Antiviral Agents
Nucleosides