Parainfluenza virus infection among adults hospitalized for lower respiratory tract infection

Clin Infect Dis. 1999 Jul;29(1):134-40. doi: 10.1086/520142.


To better define the contribution of human parainfluenza viruses (HPIVs) to lower respiratory tract infection in adults, we tested acute- and convalescent-phase serum specimens from hospitalized adults participating in a population-based prospective study of lower respiratory tract infection during 1991-1992. We tested all available specimens from the epidemic seasons for each virus and approximately 300 randomly selected specimens from the corresponding off-seasons for antibodies to HPIV-1, HPIV-2, or HPIV-3. During the respective epidemic season, HPIV-1 infection was detected in 18 (2.5%) of 721 and HPIV-3 infection in 22 (3.1%) of 705 patients with lower respiratory tract infection. Only 2 (0.2%) of 1,057 patients tested positive for HPIV-2 infection. No HPIV-1 infections and only 2 (0.7% of 281 patients tested) HPIV-3 infections were detected during the off-seasons. HPIV-1 and HPIV-3 were among the four most frequently identified infections associated with lower respiratory tract infection during their respective outbreak seasons.

MeSH terms

  • Adult
  • Disease Outbreaks
  • Female
  • Hospitalization
  • Humans
  • Male
  • Parainfluenza Virus 1, Human* / immunology
  • Parainfluenza Virus 2, Human* / immunology
  • Parainfluenza Virus 3, Human* / immunology
  • Paramyxoviridae Infections / epidemiology
  • Paramyxoviridae Infections / immunology
  • Paramyxoviridae Infections / virology*
  • Patient Discharge
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / virology*
  • Prospective Studies