Comparison of ondansetron and tropisetron combined with droperidol for the prevention of emesis in women with a history of post-operative nausea and vomiting

Eur J Anaesthesiol. 1999 Jun;16(6):390-5. doi: 10.1046/j.1365-2346.1999.00504.x.


The anti-emetic efficacy of prophylactic ondansetron and tropisetron in combination with a low dose of droperidol in patients with high probability for post-operative nausea and vomiting undergoing gynaecological laparoscopy was compared. Patients were randomly allocated in a double-blind manner to receive either ondansetron 8 mg (n = 45) or tropisetron 5 mg (n = 43) at the end of surgery. A standardized general anaesthetic technique was used, including droperidol 0.75 mg. The incidence of nausea was 36% and 49% (P = 0.28), and vomiting occurred in 13% and 14% of the patients in the ondansetron and tropisetron groups, respectively. The onset time for rescue medication was significantly sooner after tropisetron than ondansetron (3 h 18 min vs. 6 h 25 min; P = 0.007). There were no statistically significant differences in efficacy between prophylactic ondansetron and tropisetron combined with droperidol in a high-risk population. However, ondansetron appeared to be more effective in preventing post-operative nausea and vomiting in the early hours after surgery compared with tropisetron.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anesthesia, General
  • Antiemetics / administration & dosage*
  • Double-Blind Method
  • Droperidol / administration & dosage*
  • Drug Therapy, Combination
  • Female
  • Gynecologic Surgical Procedures
  • Humans
  • Indoles / administration & dosage*
  • Laparoscopy
  • Middle Aged
  • Ondansetron / administration & dosage*
  • Postoperative Nausea and Vomiting / drug therapy
  • Postoperative Nausea and Vomiting / prevention & control*
  • Risk Factors
  • Serotonin Antagonists / administration & dosage*
  • Tropisetron


  • Antiemetics
  • Indoles
  • Serotonin Antagonists
  • Ondansetron
  • Tropisetron
  • Droperidol