Relief from profound fatigue associated with chronic liver disease by long-term ondansetron therapy

Lancet. 1999 Jul 31;354(9176):397. doi: 10.1016/S0140-6736(99)02936-0.

Abstract

A woman with chronic hepatitis C and profound fatigue became symptomfree when treated long-term with ondansetron 4 mg twice daily. Altered central serotoninergic neurotransmission may contribute to fatigue complicating chronic liver disease.

Publication types

  • Case Reports
  • Clinical Trial
  • Letter
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Fatigue / drug therapy*
  • Female
  • Hepatitis C, Chronic / drug therapy*
  • Humans
  • Liver Function Tests
  • Ondansetron / administration & dosage*
  • Ondansetron / adverse effects
  • Serotonin Antagonists / administration & dosage*
  • Serotonin Antagonists / adverse effects

Substances

  • Serotonin Antagonists
  • Ondansetron