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Comparative Study
, 163 (4), 1737-41

Cutting Edge: Immature Dendritic Cells Generated From Monocytes in the Presence of TGF-beta 1 Express Functional C-C Chemokine Receptor 6

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  • PMID: 10438902
Comparative Study

Cutting Edge: Immature Dendritic Cells Generated From Monocytes in the Presence of TGF-beta 1 Express Functional C-C Chemokine Receptor 6

D Yang et al. J Immunol.

Abstract

Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so. We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha). These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein. Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.

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