[The species characteristics of the elastolytic system of the arteries and veins in the early stages of experimental tunica media calcinosis and atherosclerosis]

Fiziol Zh. 1999;45(3):43-51.
[Article in Ukrainian]

Abstract

The role of the elastolytic system arterial and venous tissues in pathogenesis of vascular pathology was investigated on rabbits and rats in experimental arterio-atherosclerosis. The obtained results indicate that elastase activity in aortic homogenates was significant higher in normal and pathological condition in rats than in rabbits. Elastase inhibitors (alpha 2-macroglobulin and alpha 1-proteinase inhibitor) also respond on angiosclerotic agent and level of alpha 2-macroglobulin increased significant in resistant animals (rats) but not in rabbits. In venous vessels determined more higher level of antielastase potential that may be explain its phenomenal resistance to different damage factors. The presented result confirm the importance of balance elastase and it inhibitors in pathogenesis of arterio-atherosclerosis.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Arteries / enzymology*
  • Arteriosclerosis / chemically induced
  • Arteriosclerosis / enzymology*
  • Calcinosis / chemically induced
  • Calcinosis / enzymology*
  • Disease Models, Animal
  • Elastic Tissue / enzymology*
  • Pancreatic Elastase / metabolism
  • Rabbits
  • Rats
  • Rats, Wistar
  • Species Specificity
  • Tunica Media / pathology*
  • Veins / enzymology*
  • alpha 1-Antitrypsin / metabolism
  • alpha-Macroglobulins / metabolism

Substances

  • alpha 1-Antitrypsin
  • alpha-Macroglobulins
  • Pancreatic Elastase