CD30 expression is common in mediastinal large B-cell lymphoma

Am J Clin Pathol. 1999 Aug;112(2):241-7. doi: 10.1093/ajcp/112.2.241.


Large B-cell lymphoma manifesting in the mediastinum shows distinctive clinical and immunophenotypic features and is recognized as a unique type of large B-cell lymphoma in the Revised European-American Lymphoma classification. Fifty-one cases of primary mediastinal large B-cell lymphoma were retrieved from the immunodiagnosis laboratory database files and were stained with anti-CD30 (Ber-H2). Of the 51 cases, 35 (69%) stained for CD30. This staining ranged from strong membrane staining of all or almost all of the neoplastic cells to positivity of rare individual cells. Eleven cases (22%) were negative; 4 (8%) were equivocal. Only 1 case was uninterpretable owing to B-5 fixation and lack of a positive internal control. Thus, the majority of mediastinal large B-cell lymphomas express the Hodgkin marker CD30. This finding may result in misdiagnosis of large cell lymphoma as Hodgkin disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm / analysis
  • Diagnosis, Differential
  • Female
  • Hodgkin Disease / diagnosis
  • Humans
  • Immunoenzyme Techniques
  • Ki-1 Antigen / analysis
  • Ki-1 Antigen / metabolism*
  • Leukocyte Common Antigens / analysis
  • Lewis X Antigen / analysis
  • Lymphoma, B-Cell / chemistry
  • Lymphoma, B-Cell / metabolism*
  • Lymphoma, B-Cell / pathology
  • Lymphoma, Large B-Cell, Diffuse / chemistry
  • Lymphoma, Large B-Cell, Diffuse / metabolism*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Male
  • Mediastinal Neoplasms / chemistry
  • Mediastinal Neoplasms / metabolism*
  • Middle Aged


  • Antigens, Neoplasm
  • Ki-1 Antigen
  • Lewis X Antigen
  • Leukocyte Common Antigens