Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops

Am J Hum Genet. 1999 Sep;65(3):885-901. doi: 10.1086/302524.


We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.

Publication types

  • Comparative Study

MeSH terms

  • Algorithms
  • Alleles
  • Bayes Theorem*
  • Female
  • Genetic Linkage / genetics*
  • Genotype
  • Humans
  • Likelihood Functions*
  • Lod Score
  • Long QT Syndrome / genetics*
  • Male
  • Pedigree
  • Phenotype
  • Recombination, Genetic