Type-2 diabetes and cognitive function in a non-demented population

Acta Neurol Scand. 1999 Aug;100(2):97-101. doi: 10.1111/j.1600-0404.1999.tb01045.x.


Objectives: To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population.

Material and methods: Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elderly population consisting of 183 NIDDM (World Health Organization, 1985) patients and 732 non-diabetic subjects.

Results: Patients with NIDDM were impaired in the Trail-Making Test parts A and C, which may be a reflection of mildly affected frontal lobe/executive functions. Women with NIDDM performed better than non-diabetic subjects in the Mini-Mental State Examination.

Conclusions: We conclude that NIDDM per se is not associated with impaired memory in the elderly, and the minor defects observed in tests of frontal lobe/executive functions are unlikely to affect daily living. In the non-demented population aged 69 78 years, NIDDM does not carry a significant risk of cognitive dysfunction, when compared to the non-diabetic subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living / psychology
  • Aged
  • Brain Damage, Chronic / diagnosis*
  • Brain Damage, Chronic / psychology
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Dementia / diagnosis
  • Dementia / psychology
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Diabetes Mellitus, Type 2 / psychology
  • Diabetic Angiopathies / diagnosis
  • Diabetic Angiopathies / psychology
  • Female
  • Humans
  • Intracranial Arteriosclerosis / diagnosis
  • Intracranial Arteriosclerosis / psychology
  • Male
  • Mental Status Schedule
  • Neuropsychological Tests
  • Risk Factors