Enteral histaminosis: Clinical implications

Inflamm Res. 1999 Jun;48(6):291-5. doi: 10.1007/s000110050462.


There is increasing evidence that enteral histaminosis is a major cause of food intolerance resulting from dysfunctional metabolism of endogenous histamine in certain food stuffs. However, this phenomenon has been poorly characterised and, due to the lack of epidemiological data, the existence of this condition has been underestimated, which may lead to incorrect diagnosis. This short commentary highlights a stricter regimen of diagnostic procedure in order to take into account the many causes of food intolerance. The underlying mechanisms ascribed particularly to non-immunologically food reactions require more rigorous research and further work is vital.

Publication types

  • Review

MeSH terms

  • Clinical Protocols
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / etiology
  • Food Hypersensitivity / therapy
  • Histamine / metabolism*
  • Humans
  • Intestinal Mucosa / metabolism*


  • Histamine