Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients

Clin Exp Immunol. 1999 Aug;117(2):350-4. doi: 10.1046/j.1365-2249.1999.00984.x.

Abstract

The immunoglobulin receptor Fc gamma RIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and gamma delta T cells, and is polymorphic. Fc gamma RIIIa-158V has a higher affinity for both monomeric and immune complexed IgG1, IgG3, and IgG4 than IIIa-158F. We determined Fc gamma RIIIa-158V/F genotypes of Japanese patients with adult periodontitis. A significant over-representation of Fc gamma RIIIa-158F was found in patients with recurrence, compared with patients without recurrence, making Fc gamma RIIIA a candidate gene for recurrence risk of adult periodontitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Alleles
  • Amino Acid Substitution / genetics
  • Amino Acid Substitution / immunology
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Periodontitis / etiology
  • Periodontitis / genetics*
  • Periodontitis / immunology*
  • Phenylalanine / genetics*
  • Polymorphism, Genetic / immunology*
  • Receptors, IgG / genetics*
  • Recurrence
  • Valine / genetics*

Substances

  • Receptors, IgG
  • Phenylalanine
  • Valine