Characterization of epithelial downgrowth by confocal microscopy

J Cataract Refract Surg. 1999 Aug;25(8):1172-4. doi: 10.1016/s0886-3350(99)00133-9.


A 43-year-old white woman with a history of multiple ocular surgeries, including 4 penetrating keratoplasties, developed a concentric retrocorneal membrane at the graft periphery in the right eye. A white-light, tandem, scanning confocal microscope using a 24x/0.60 contact objective was used to examine the right eye in vivo. At the endothelial layer, confocal microscopic images similar to corneal epithelial cells were detected at the graft periphery. Unlike normal endothelial cells, the imaged cells demonstrated easily recognizable nuclei.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Corneal Diseases / etiology
  • Corneal Diseases / pathology*
  • Epithelium, Corneal / pathology*
  • Female
  • Humans
  • Keratoplasty, Penetrating / adverse effects*
  • Microscopy, Confocal