Analysing the developing lymphocyte system of neonates and infants

Eur J Pediatr. 1999 Aug;158(8):611-7. doi: 10.1007/s004310051162.


Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children.

Conclusion: In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunophenotyping*
  • Infant
  • Infant, Newborn
  • Lymphatic System / growth & development*
  • Lymphocyte Count
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / physiology
  • Lymphocytes / immunology
  • Lymphocytes / physiology*