Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients

Eur J Gastroenterol Hepatol. 1999 Jul;11(7):717-20. doi: 10.1097/00042737-199907000-00006.


Objective: Infection with Helicobacter pylori is associated with gastric cancer. However, a hereditary risk of gastric cancer has also been reported. Hence, we decided to evaluate H. pylori gastritis in relatives of gastric cancer patients in comparison with matched controls.

Design: Case-controlled study.

Methods: A total of 237 patients with merely H. pylori gastritis (i.e. not associated with either peptic ulcer or gastric malignancy), and either first-degree (93.7%) or second-degree (6.3%) relatives with gastric cancer, were age- and sex-matched with 237 patients with H. pylori gastritis unassociated with a family history of gastric cancer. From each patient, antral and corpus biopsy specimens were obtained and investigated for degree (lymphocyte/plasma cell infiltration) and activity (polymorph infiltration) of gastritis (score: 0-4). Intestinal metaplasia was recorded as present or absent.

Results: The results show that relatives of gastric cancer patients have a significantly greater expression of gastritis due to a higher grade of gastritis in the antrum and corpus (P < 0.0001) and a greater activity of gastritis in the corpus (P < 0.0001). Intestinal metaplasia occurs more often in relatives of gastric cancer patients (antrum: P < 0.0001; corpus: P = 0.0237).

Conclusion: Since the grade of H. pylori gastritis in relatives of gastric cancer patients is significantly higher than in controls, there appears to be a genetic susceptibility influencing the expression of H. pylori gastritis.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Gastritis / epidemiology
  • Gastritis / genetics*
  • Gastritis / microbiology*
  • Genetic Predisposition to Disease
  • Helicobacter Infections / epidemiology
  • Helicobacter Infections / genetics*
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Risk Factors
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / genetics*