Spatial and temporal expression of p57(KIP2) during murine lens development

Mech Dev. 1999 Aug;86(1-2):165-9. doi: 10.1016/s0925-4773(99)00106-9.


The expression patterns of p57(KIP2), an important cyclin-dependent kinase inhibitor in the lens, is investigated. This study shows that the expression of p57 mRNA throughout lens morphogenesis and growth correlates with lens cell withdrawal from the cell cycle (shown by changing patterns of BrdU incorporation) and the onset of lens fibre differentiation (shown by beta-crystallin expression). p57 expression at the early stages of fibre differentiation make it a useful marker for the initiation of this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cell Cycle / genetics
  • Cell Differentiation / genetics
  • Cell Division / genetics
  • Cyclin-Dependent Kinase Inhibitor p57
  • Gene Expression Regulation, Developmental*
  • Lens, Crystalline / embryology*
  • Lens, Crystalline / growth & development*
  • Mice
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism


  • Cdkn1c protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p57
  • Nuclear Proteins