Receptor mediated subversion of macrophage cytokine production by intracellular pathogens

Curr Opin Immunol. 1999 Aug;11(4):406-11. doi: 10.1016/s0952-7915(99)80068-5.


Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.

Publication types

  • Review

MeSH terms

  • Animals
  • HIV Infections / immunology
  • Histoplasmosis / immunology
  • Humans
  • Infections / immunology*
  • Interleukin-12 / biosynthesis*
  • Leishmaniasis / immunology
  • Macrophages / immunology*
  • Measles / immunology
  • Receptors, Immunologic / physiology*


  • Receptors, Immunologic
  • Interleukin-12