Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic

Curr Opin Immunol. 1999 Aug;11(4):380-6. doi: 10.1016/S0952-7915(99)80064-8.


Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8(+) cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / immunology*
  • Adenovirus E1A Proteins / physiology
  • Adenovirus E1B Proteins / physiology
  • Animals
  • Apoptosis
  • Genetic Therapy
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • T-Lymphocytes, Cytotoxic / immunology


  • Adenovirus E1A Proteins
  • Adenovirus E1B Proteins
  • Histocompatibility Antigens Class I