Neural mechanisms underlying amblyopia

Curr Opin Neurobiol. 1999 Aug;9(4):480-6. doi: 10.1016/s0959-4388(99)80072-5.


The nature of the neural basis of amblyopia is a matter of some debate. Recent neurophysiological data show correlates of amblyopia in the spatial properties of neurons in primary visual cortex. These neuronal deficits are probably the initial manifestation of the visual loss, but there are almost certainly additional deficits at higher levels of the visual pathways.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amblyopia / etiology
  • Amblyopia / physiopathology*
  • Animals
  • Anisometropia / etiology
  • Anisometropia / physiopathology*
  • Contrast Sensitivity / physiology*
  • Humans
  • Strabismus / etiology
  • Strabismus / physiopathology*
  • Visual Cortex / physiology