Molecular mechanisms of vertebrate photoreceptor light adaptation

Curr Opin Neurobiol. 1999 Aug;9(4):410-8. doi: 10.1016/S0959-4388(99)80062-2.


An important recent advance in the understanding of vertebrate photoreceptor light adaptation has come from the discovery that as many as eight distinct molecular mechanisms may be involved, and the realization that one of the principal mechanisms is not dependent on calcium. Quantitative analysis of these mechanisms is providing new insights into the nature of rod photoreceptor light adaptation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Ocular / physiology*
  • Animals
  • Calmodulin / physiology
  • Cyclic GMP / physiology
  • Guanylate Cyclase / physiology
  • Humans
  • Photoreceptor Cells, Vertebrate / physiology*
  • Retinal Rod Photoreceptor Cells / physiology
  • Signal Transduction / physiology*


  • Calmodulin
  • Guanylate Cyclase
  • Cyclic GMP