Dendritic lh normalizes temporal summation in hippocampal CA1 neurons

Nat Neurosci. 1999 Jun;2(6):508-14. doi: 10.1038/9158.


Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Electric Conductivity
  • Electric Stimulation
  • Excitatory Postsynaptic Potentials / physiology
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Neurons / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Synapses / physiology
  • Time Factors