The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

Nature. 1999 Aug 5;400(6744):532-8. doi: 10.1038/22964.


Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Centromere
  • Chromosome Mapping
  • Chromosomes
  • DNA, Protozoan
  • Genome, Protozoan*
  • Molecular Sequence Data
  • Plasmodium falciparum / genetics*
  • Protozoan Proteins / genetics
  • Sequence Analysis, DNA
  • Telomere


  • DNA, Protozoan
  • Protozoan Proteins

Associated data

  • GENBANK/AL008970
  • GENBANK/AL034556
  • GENBANK/AL034559
  • GENBANK/AL034560
  • GENBANK/Z97348
  • GENBANK/Z98551