The role of intrahepatic gammadelta-T cells for liver injury induced by Salmonella infection in mouse

Microbiol Immunol. 1999;43(5):461-9. doi: 10.1111/j.1348-0421.1999.tb02429.x.

Abstract

Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-delta knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (UC7-13D5) to stimulate gammadelta-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that gammadelta-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Genes, T-Cell Receptor delta / genetics*
  • Interferon-gamma / biosynthesis
  • Liver / immunology
  • Liver / pathology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Antigen, T-Cell, gamma-delta / immunology*
  • Salmonella / growth & development
  • Salmonella Infections, Animal / immunology*
  • Salmonella Infections, Animal / pathology
  • T-Lymphocytes / immunology*

Substances

  • Receptors, Antigen, T-Cell, gamma-delta
  • Interferon-gamma
  • Alanine Transaminase