Design and application of multimodular peptide synthetases

Curr Opin Biotechnol. 1999 Aug;10(4):341-8. doi: 10.1016/S0958-1669(99)80062-7.


Nonribosomal peptide synthetases produce bioactive peptides of great structural diversity. Their modular organization makes them amenable to the construction of hybrid enzymes that synthesize novel products. New strategies for combinatorial approaches are being developed from the recent advances in nonribosomal peptide synthesis on the genetic, biochemical and structural level.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biotechnology
  • Drug Design
  • Enzyme Precursors / chemistry
  • Enzyme Precursors / genetics
  • Enzyme Precursors / metabolism
  • In Vitro Techniques
  • Peptide Synthases / chemistry*
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism
  • Protein Engineering
  • Protein Processing, Post-Translational


  • Enzyme Precursors
  • Peptide Synthases