Disease models provide insights into post-golgi protein trafficking, localization and processing

Curr Opin Cell Biol. 1999 Aug;11(4):489-94. doi: 10.1016/s0955-0674(99)80070-2.


Over the past two years, the use of in vitro systems and the identification of autoantibodies to Golgi proteins have provided important new tools for analyzing vesicle and cargo trafficking in the distal secretory pathway. In addition, the phenotypic characterization of mice with knockouts of various prohormone convertases has led to significant progress in understanding the biological relevance of prohormone processing in post-Golgi compartments.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cytoplasmic Granules
  • Disease Models, Animal
  • Endopeptidases / metabolism
  • Golgi Apparatus / metabolism*
  • Humans
  • Mice
  • Oculocerebrorenal Syndrome / metabolism
  • Protein Processing, Post-Translational*
  • Proteins / metabolism*


  • Proteins
  • Endopeptidases