Wnt signaling and dorso-ventral axis specification in vertebrates

Curr Opin Genet Dev. 1999 Aug;9(4):405-10. doi: 10.1016/S0959-437X(99)80061-6.


The dorso-ventral axis is specified in vertebrates through the formation of a dorsal signaling center known as the Spemann organizer. This process depends on signal transduction by beta-catenin that can be regulated by secreted Wnt proteins. Recent discoveries of new players in this signaling pathway have narrowed down the search for the initial cues for axis specification in vertebrate embryos.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Embryonic and Fetal Development*
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction*
  • Vertebrates / embryology*
  • Wnt Proteins
  • Zebrafish Proteins*


  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Zebrafish Proteins