Epithelial cell movements and interactions in limb, neural crest and vasculature

Curr Opin Genet Dev. 1999 Aug;9(4):455-60. doi: 10.1016/s0959-437x(99)80069-0.


Formation of the thickened apical ectodermal ridge of developing vertebrate limbs appears to be a complex process. Direct connections to molecular controls of cell migratory machinery have been shown for first time in neural crest migration. New unsuspected roles are emerging for ephrin ligand/Eph receptor signalling in vascular morphogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Vessels / embryology*
  • Cell Movement*
  • Epithelial Cells / cytology*
  • Extremities / embryology*
  • Nervous System / embryology*
  • Vertebrates / embryology*