Fringe, Notch, and making developmental boundaries

Curr Opin Genet Dev. 1999 Aug;9(4):434-41. doi: 10.1016/S0959-437X(99)80066-5.

Abstract

Multiple mechanisms are involved in positioning and restricting specialized dorsal-ventral border cells in the Drosophila wing, including modulation of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ventral cells in the Drosophila eye, establishing an organizer of eye growth and patterning along the dorsal-ventral midline. Fringe-dependent modulation of Notch signaling also plays a key role in Drosophila leg segmentation and growth. Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila / embryology*
  • Drosophila Proteins
  • Embryo, Nonmammalian / metabolism
  • Embryonic Development
  • Insect Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • N-Acetylglucosaminyltransferases*
  • Receptors, Notch

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch
  • N-Acetylglucosaminyltransferases
  • fng protein, Drosophila