Diverse initiation in a conserved left-right pathway?

Curr Opin Genet Dev. 1999 Aug;9(4):422-6. doi: 10.1016/s0959-437x(99)80064-1.


Preceding stereotypical left-right asymmetric morphogenesis, asymmetric gene expression patterns of nodal and pitx2 are very similar in major groups of vertebrates. I propose that these conserved expression patterns are indicative of 'left-right' phylotypic stages' of development. It is not known whether these patterns are initiated by conserved or divergent developmental mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Embryonic and Fetal Development*
  • Gene Expression Regulation, Developmental
  • Mesoderm