Vitamin B status in patients with chronic fatigue syndrome

J R Soc Med. 1999 Apr;92(4):183-5. doi: 10.1177/014107689909200405.

Abstract

Some patients with chronic fatigue syndrome say they benefit from taking vitamin supplements. We assessed functional status for the B vitamins pyridoxine, riboflavin and thiamine in 12 vitamin-untreated CFS patients and in 18 healthy controls matched for age and sex. Vitamin-dependent activities--aspartate aminotransferase (AST) for pyridoxine, glutathione reductase (GTR) for riboflavin, transketolase (TK) for thiamine--were measured in erythrocyte haemolysates before and after in-vitro addition of the relevant vitamin. For all three enzymes basal activity (U/g Hb) was lower in CFS patients than in controls: AST 2.84 (SD 0.62) vs 4.61 (1.43), P < 0.001; GTR 6.13 (1.89) vs 7.42 (1.25), P < 0.04; TK 0.50 (0.13) vs 0.60 (0.07), P < 0.04. This was also true of activated values: AST 4.91 (0.54) vs 7.89 (2.11), P < 0.001; GTR 8.29 (1.60) vs 10.0 (1.80), P < 0.001; TK 0.56 (0.19) vs 0.66 (0.08), P < 0.07. The activation ratios, however, did not differ between the groups. These data provide preliminary evidence of reduced functional B vitamin status, particularly of pyridoxine, in CFS patients.

MeSH terms

  • Adult
  • Aspartate Aminotransferases / blood
  • Erythrocytes / drug effects
  • Erythrocytes / enzymology
  • Fatigue Syndrome, Chronic / blood*
  • Female
  • Glutathione Reductase / blood
  • Humans
  • Male
  • Middle Aged
  • Pyridoxine / pharmacology
  • Pyridoxine / physiology
  • Riboflavin / pharmacology
  • Riboflavin / physiology
  • Thiamine / pharmacology
  • Thiamine / physiology
  • Transketolase / blood
  • Vitamin B Complex / physiology*

Substances

  • Vitamin B Complex
  • Glutathione Reductase
  • Transketolase
  • Aspartate Aminotransferases
  • Pyridoxine
  • Riboflavin
  • Thiamine